Last but not least, many of the outcome metrics reported in fewer studies could not be analyzed, such as skeletal muscle mass, glycated hemoglobin A1c (HbA1c), IGF-1, and other inflammation markers such as serum amyloid A (SAA) and procalcitonin (PCT), which hinders understanding of exercise’s biological pathways in CRC. This evidence concerns the gene IGF1 and colorectal carcinoma.