NO administration affects GSCs by slowing their growth and enhancing their susceptibility to chemotherapy, which could have implications for long-term management.BET inhibitor targeting of iNOS expression in cancer cells. Such targeting can markedly improve therapeutic efficacy in glioblastomaTargeting the nitrosative stress with HU-53 and HU-54 may be a promising therapeutic strategy for glioblastoma treatment. This evidence concerns the gene NOS2 and glioblastoma.