In contrast, SOM-PTEN-KO mice showed indications of anxiety-like responses in the hole board test of investigative behavior, as SOM-PTEN-KO mice spent more time in the corners of the arena when the hole board was present, suggesting a tendency for anxiety-like behavior in more stimulating environments, though they did not display restricted-repetitive motion as measured by repetitive hole-poking (Figures 1i, j). Here, PTEN is linked to Anxiety.