SHANK3 and Anxiety: Dysregulation of fear, anxiety, and sensory sensitivity has also been observed in some PTEN models (Kwon et al., 2006; Vogt et al., 2015; Clipperton-Allen and Page, 2014) as well as in other mouse models of ASD such as SHANK3 (Peça et al., 2011; Jiang and Ehlers, 2013) and CNTNAP2 (Peñagarikano et al., 2011).