We focused on SOM-PTEN-KO because the number of SOM+ neurons is reduced in the Nkx2.1 Cre MGE conditional PTEN KO model, showing a role for PTEN in the early development of inhibitory neurons from neuronal progenitors (Vogt et al., 2015) and because SOM-PTEN-KO is sufficient for the expression of an ASD behavioral phenotype with a strong anxiety component (Shin et al., 2021). This evidence concerns the gene GRHL3 and Anxiety.