During days 1 to 3 (D1-3), the relative expression of miR-146b-5p, CD3%, and CD4% demonstrated negative correlations with the APACHE II scores in sepsis patients (r = -0.224, p = 0.0241; r = -0.280, p = 0.0046; r = -0.240, p = 0.0156). The gene discussed is CD4; the disease is Sepsis.