CD6 and psoriasis: Thus, Cd6-/- mice show protection or attenuation in experimental autoimmune encephalomyelitis (EAE), autoimmune uveitis, and imiquimod-induced psoriasis models (21, 23, 24), while experience more severe collagen-induced arthritis (CIA), chronic graft-versus-host disease (cGvHD)-induced lupus-like disease, and antiviral humoral responses (22, 25, 26).