Oxymatrine possesses a variety of pharmacological effects, including antiviral, antifibrotic and other immunomodulatory effects, effectively inhibits CAF activation and promotes TIL infiltration in tumors, and has now been shown to inhibit tumor growth in a variety of tumor cell lines, including hepatocellular carcinomas, lung carcinomas, colorectal carcinomas, and breast carcinomas, as well as to suppress tumor growth through the regulation of miRNAs and a variety of signaling pathways, including STAT5, EGFR, NF- κB and PI3K/Akt in tumor development, progression and drug resistance (31–33). Here, AKT1 is linked to hepatocellular carcinoma.