Since IBD is heavily mediated by T cell responses, and IL-36 cytokines are known to promote the recruitment of T cells (30) and induce the secretion of other pro-inflammatory cytokines (31), we investigated the influence of IL-36γ on naïve CD4+ T cells and colitis using a well-known adoptive T cell transfer model of colitis (10). This evidence concerns the gene CD4 and colitis.