Given that IL-18 is found in elevated levels in UC patients, a study that used wild type (WT), IL-18-/-, and IL-18R-/- mice in DSS colitis model found that IFNγ production and IL-17 producing CD4+ T cells were reduced in the colons of both knockout models, along with less severe colitis than WT. The gene discussed is IL18; the disease is colitis.