A meta-analysis by Chen et al., which included 2,629 AD patients and 2,049 controls, found that cerebrospinal fluid (CSF) levels of IL-1β, IL-6, IL-8, TNF-α, TGF-β, and MCP-1 were significantly higher in AD patients compared to controls (36). The gene discussed is CXCL8; the disease is Alzheimer disease.