Studies have demonstrated that exosomes derived from bone marrow MSCs (BMSC-Exo) overexpressing miR-30e can ameliorate myocardial infarction in rats by inhibiting LOX-1 expression and downregulating NF-κB p65/Caspase-9 signaling, thereby reducing myocardial pathological damage and fibrosis (85). This evidence concerns the gene CASP9 and myocardial infarction.