(114) tested relatively common METTL3 mutations in cancer using the Cry2 LLPS system and found that the R415C and E516K mutants were unable to undergo LLPS in the presence of Cry2 fusion and blue-light irradiation, suggesting that the disruption of LLPS resulting from mutations in METTL3 may alter epigenetic inheritance, which may in turn promote tumorigenesis. Here, METTL3 is linked to cancer.