SOCS3 and Sepsis: Previous studies have shown that Socs1 and Socs3 can target the Traf6 complex and inhibit signaling pathways associated with inflammation and innate immunity (59) LPS treatment induces Socs1 m6A methylation and sustains SOCS1 induction by decreasing Fto mRNA expression, which maintains the negative feedback control of macrophage cytokine storm in sepsis (22).