Conversely, exogenous lentivirus LV-Fto infection of wild-type BMDMs followed by LPS stimulation increased TNF-α/IL-1β/IL-6 cytokine secretion compared to the LV-Ctrl group (Supplementary Figure 4B). Moreover, the rescue of Fto in myeFto-/- BMDMs by LV-Fto also led to increased secretion of these cytokines during LPS stimulation (Supplementary Figure 4C). The gene discussed is FTO; the disease is infection.