BMP2 and cardiovascular disorder: By analogy, EGCG can also improve cardiovascular disease by mediating Tryptophan Metabolism, and abnormal Tryptophan Metabolism will lead to abnormal serotonin levels, and excessive serotonin will affect the function of osteoblasts and osteoclasts, which will mediate the expression of bone metabolism-related factors, such as bone morphogenetic protein-2, to promote the calcification of VSMCs.