The loss of function of Yap1-conditioned knockout in this pathway leads to mitotic arrest and impaired spermatogenesis in mice [92], and abnormalities in the YAP1/RAD21/NEDD4 axis are associated with human non-obstructive azoospermia [92], highlighting new targets for clinical applications of the cohesin complex in treating male infertility. This evidence concerns the gene NEDD4 and male infertility.