SMC3 and acute myeloid leukemia: In the context of haploinsufficiency, a decline in SMC3 expression has been observed to enhance the self-renewal of HSCs by reducing the chromatin accessibility of differentiation-related genes (e.g., Pou2af1), increasing the pluripotency network (e.g., Hmga2 and Pbx3), and synergistically promoting the genesis of AML in conjunction with Flt3-ITD.