In addition, this study found that drugs used to treat mucopolysaccharide storage disease (e.g., galsulfase, idursulfase, laronidase, and elosulfase alfa), and the third-generation bisphosphonates risedronate and zoledronic acid, used to treat hearing loss due to pediatric sclerosis, have also been associated with ototoxicity signaling correlations (Quesnel et al., 2012). This evidence concerns the gene IDS and hearing loss disorder.