Research has shown that targeting the TLR3/4 and NLRP3/NF-κB pathways can lead to a decrease in oxidative stress and provide anti-inflammatory benefits in a mouse model of ARDS induced by LPS/POLY I:C, ultimately enhancing the functionality of both the lungs and heart (Jain et al., 2023). Here, NFKB1 is linked to acute respiratory distress syndrome.