MAPK3 and acute respiratory distress syndrome: Recent studies, including those utilizing Nox2−/− mice models {Hook, 2019 #668}, have further elucidated the role of NOX2 in neutrophil-mediated ROS production, demonstrating that its activation by GPR84 exacerbates LPS-induced ALI through Lyn, AKT, and ERK1/2 signaling pathways, highlighting a specific molecular cascade driving oxidative stress in ARDS (Wang et al., 2023).