The key findings are summarized below: (i) MI occurs with EC ferroptosis, (ii) post-infarction EC ferroptosis mediates ventricular remodeling, and its mechanism is probably associated with inhibiting ALDH2 signaling, and (iii) Tan I suppresses EC ferroptosis, promotes angiogenesis, and improves ventricular remodeling post-MI by activating ALDH2 signaling. Here, ALDH2 is linked to infarction.