Levels of ferroptosis-related indicators were consistent with expectations, showing that Fer-1 significantly suppressed EC ferroptosis, promoted angiogenesis and inhibited post-MI ventricular remodeling, comparable to the effects of Tan I. This study further confirmed that Fer-1 activated ALDH2 and upregulated the expression of ALDH2, xCT, and GPX4, which echoed the mechanism of Tan I. The present findings strongly suggest an association between MI and EC ferroptosis. The gene discussed is SLC7A11; the disease is myocardial infarction.