ALDH2 and myocardial infarction: Levels of ferroptosis-related indicators were consistent with expectations, showing that Fer-1 significantly suppressed EC ferroptosis, promoted angiogenesis and inhibited post-MI ventricular remodeling, comparable to the effects of Tan I. This study further confirmed that Fer-1 activated ALDH2 and upregulated the expression of ALDH2, xCT, and GPX4, which echoed the mechanism of Tan I. The present findings strongly suggest an association between MI and EC ferroptosis.