To investigate the sensitivity of chemoresistant B cell lymphoma towards Gal-9 treatment, Vincristine (VNC) and Doxurubicin (DOX) resistant Sc-1 cells were generated by culturing under constant pressure of increasing doses of chemotherapy (Figure 5A), resulting in the cell line panel: Sc-1-parental (Sc-1-PAR) and Sc-1-resistant (Sc-1-RES). Here, LGALS9 is linked to B-cell non-Hodgkin lymphoma.