NLRP3 and breast carcinoma: Analysis of keywords and subject terms revealed prevalent terms in this research domain such as “breast cancer,” “chemotherapy,” “doxorubicin,” “drug delivery,” and “nanoparticles.” This analysis identified two critical research gaps requiring urgent attention: the insufficient understanding of cardiotoxicity mechanisms (e.g., ferroptosis, NLRP3 inflammasome activation) associated with ICIs, and the lack of established clinical standardization frameworks for promising preclinical nanocarrier strategies.