In addition, CAFs actively polarize tumor-associated macrophages (TAMs) and neutrophils (TANs) toward protumor phenotype (M2 and N2, respectively) via factors like IL-4, IL-6, IL-8, GM-CSF, CXCL8, and CXCL12 (322, 323). The gene discussed is CXCL8; the disease is neoplasm.