EGFR and non-small cell lung carcinoma: In one of the largest retrospective studies analyzing data from over 8,000 patients with NSCLC, the most common single nucleotide variants (SNV) among 189 patients under 50 years old were TP53 (57.1%), KRAS (15.5%), EGFR (21.4%), STK11 (10.1%), SMARCA4 (7.7%), and LRP1B (4.8%) (70, 71).