CD4 and neoplasm: The two types of conventional DCs (cDCs) are cDC1s (recognized in mice by CD103 expression), which are responsible for anti-tumor activity due to the presentation of tumor-associated antigens to CD8+ T cells, and cDC2s (recognized in mice by CD11b expression), an inducer of the CD4+ helper T cell response, and their role in the immune activity to tumor cells is not well described (23).