ABCG2 and cancer: Figure 7B identifies 12 metabolic pathways that tend to be upregulated, including Aminoacyl-tRNA biosynthesis, Biosynthesis of cofactors, Antifolate resistance, Starch and sucrose metabolism, Folate biosynthesis, Central carbon metabolism in cancer, Valine, leucine, and isoleucine biosynthesis, Mineral absorption, ABC transporters, D-Amino acid metabolism, Arginine and proline metabolism, and Drug metabolism – other enzymes.