INS and Insulin resistance: By participating in the regulation of signal molecules such as nuclear factor kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), cytokine signaling 3 (SOCS-3) and insulin receptor substrate (IRS), IL-6 promotes oxidative stress and inflammatory responses, leading to impaired biological effects of insulin, thus mediates insulin resistance [22,23].