An elevated percentage of T cell subsets that had elevated expression of inhibitory receptors such as CD160, CD152, CD279 and CD278, the relative abundance of naïve Tregs and activated cTFH amongst total T cells and correlation with disease stage indicates that a skewed T cell profile may contribute to immune editing and disease development in Multiple myeloma [52] It may be important to conduct a paired analysis of T cell profiling in peripheral blood and bone marrow to identify the impact of T cell abnormalities in NDMM. The gene discussed is ICOS; the disease is plasma cell myeloma.