Knockdown of BAF60c in HF rats restored oxidative metabolism, improved glucose uptake, enhanced mitochondrial function, and reduced apoptosis by activating the Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha/Peroxisome Proliferator-Activated Receptor Alpha/Mechanistic Target of Rapamycin (PGC1α/PPARα/mTOR) signaling pathway. The gene discussed is SMARCD3; the disease is hydrops fetalis.