Notably, recent research has demonstrated distinct and even opposing functions of BAF60c and BAF60a in SMC differentiation, vascular homeostasis, and the development of diseases such as abdominal aortic aneurysm (AAA) and atherosclerosis (Zhao et al., 2022; Chang et al., 2020). Here, SMARCD1 is linked to abdominal aortic aneurysm.