Viral replication, as indicated by viral copy numbers, was significantly increased following infection and in contrast to ICAM and LDLR expression levels in infected, treated, cultures, viral copy numbers were significantly lower in the AZM pre-treated, HRV-1b infected cultures, compared to those infected with HRV-1b only (Figure 2C; 1.2 × 107 ± 2.4 × 107 (+/+) versus 4.8 × 107 ± 2.9 × 107 (+/−); p < 0.05). This evidence concerns the gene LDLR and infection.