In glioblastoma, long eccDNAs carrying EGFR amplicons form a super-enhancer structure, driving the sustained activation of oncogenes and thus influencing the tumor progression (Wu et al., 2019; Morton et al., 2019; Zhu et al., 2021; Karami et al., 2022; Nikolaev et al., 2014). This evidence concerns the gene EGFR and neoplasm.