EGFR and neoplasm: In colorectal cancer, long eccDNA carrying genes such as DHFR and EGFR induces the drug resistance in tumor cells (Morales et al., 2009; Morales et al., 2005; Ooi et al., 2004; Chen et al., 2023); while in neuroblastoma, patients carrying MYCN-amplified eccDNA show an even lower survival rate (Karami et al., 2022; Nathanson et al., 2014; Chapman et al., 2023).