NC-SNAP may represent primary age-associated tauopathy, which is characterized by pathology that is similar to neurofibrillary tangles in preclinical Alzheimer’s disease.56 Persons with NC-SNAP may be resistant to amyloid, although amyloid resistance is often associated with specific genetic variants.57 Nonetheless, apart from APOE, our study did not support this notion. This evidence concerns the gene APOE and Alzheimer disease.