APOE and early-onset autosomal dominant Alzheimer disease: NC-SNAP may represent primary age-associated tauopathy, which is characterized by pathology that is similar to neurofibrillary tangles in preclinical Alzheimer’s disease.56 Persons with NC-SNAP may be resistant to amyloid, although amyloid resistance is often associated with specific genetic variants.57 Nonetheless, apart from APOE, our study did not support this notion.