SMAD2 and cataract: Notably, Janus kinase 1 (JAK1), SMAD family member 2 (SMAD2), MYD88, and p-STAT3 are strongly associated with the development of cataracts as well as some fibrotic diseases.33, 34, 35, 36 Subsequently, Western blot analysis was employed to screen for potential downstream pathways influenced by NR2F1.