ARNTL is an important regulator of normal physiological functions in organisms, and its mutation or aberrant expression has been associated with infertility, gluconeogenesis, inflammatory lung disease, lipogenesis, and altered sleep patterns.29, 30, 31, 32, 33, 34, 35 Therefore, we hypothesized that the disruption of the BTB and the dysfunction of spermatogenesis induced by CPF may be linked to ferroptosis mediated by clockophagy. Here, BMAL1 is linked to Infertility.