EPCAM and breast carcinoma: SERS spectroscopy has also been used to detect the expression of membrane surface markers, as was the example of EpCAM in the MDA‐MB‐435 and SKBR3 breast cancer cell lines, co‐encapsulated with gold nanostars in an optofluidic device.[93] Despite these applications, single‐cell analysis in cell‐laden droplets can still lack the necessary sensitivity when compared with standard approaches.