Instead, CD40 on CD14‐CD16+ monocyte (PIVW: 0.034, ORIVW: 0.965, 95% CI: 0.933‐0.997) and CD8 on Effector Memory CD8+ T cell (PIVW: 7.24×10−4, ORIVW: 0.921, 95% CI: 0.878‐0.966) were found to reduce the risk of migraine. Here, CD40 is linked to migraine disorder.