2024). However, it is still controversial that inflammatory factors mediate the occurrence of migraine. A study found that migraine patients had fewer regulatory T cells in their blood compared to healthy individuals (Faraji et al. 2021). Another study showed that migraine sufferers had unusual plasma cytokine levels, with higher interleukin 1‐beta (IL‐1β) and interleukin 6 (IL‐6), but lower interleukin 10 (IL‐10) (Balcziak and Russo 2022; Ha and Chu 2024). However, a 2021 study found no significant difference in IL‐1β levels between migraine patients and controls (Taheri et al. 2021). Here, IL6 is linked to migraine disorder.