For migraine, it was observed that CD27 on memory B cells (PIVW: 0.023, ORIVW: 1.043, 95% CI: 1.005‐1.083) and CD27 on unswitched memory B cell (PIVW: 0.023, ORIVW: 1.043, 95% CI: 1.005‐1.083) CD40 on CD14‐ CD16+ monocyte (PIVW: 0.023, ORIVW: 1.043, 95% CI: 1.005‐1.083) were significantly associated with an increased risk. The gene discussed is CD14; the disease is migraine disorder.