In addition, to investigate whether the knockdown of DEC2 had any effect on other neuropsychiatric behaviors, we performed a battery of behavioral tests, including the open field test (OFT) and the elevated plus maze test (EPM) to evaluate locomotor activity and anxiety‐related behavior, as well as the sucrose preference test (SPT) and the tail suspension test (TST) to analyze depression‐related behavior (Figure S2B, Supporting Information). Here, BHLHE41 is linked to major depressive disorder.