HNF4A and hepatocellular carcinoma: The top 2 highly expressed TFs (HNF4A and FOXM1) whose motifs were enriched in regions with increased accessibility and the top 2 downregulated TFs (ZNF682 and ZNF354C) whose motifs were enriched in regions with decreased accessibility in C. sinensis+ HCC tumors are shown in Fig. 2b.