Interestingly, performing RNA-seq analysis on PHGDH wild-type and PHGDH-silenced CRC cells, we identified that high PHGDH levels promote the activation of the Hedgehog (HH) signaling, a central pathway during embryonic development, whose deregulation is involved in crucial stages of carcinogenesis in different types of tumors [18]. The gene discussed is PHGDH; the disease is colorectal carcinoma.