Moreover, the report of PIL associated with tuberous sclerosis of Bourneville with TSC2-gene mutation in a 2-year-old child described a favorable evolution with sirolimus progressively increased to 0.61 mg/kg and plasma levels reaching 10.7 ng/mL (reference level: 3.0–18.0 ng/mL) [34]. The gene discussed is TSC2; the disease is tuberous sclerosis.