SOS1 and aortic stenosis: Very rare familial forms also exist [1, 7] that are more frequent in association with certain syndromes, notably: RASopathies (Noonan, ORPHA:648, protein tyrosine phosphatase non-receptor type-11 (PTPN11, rat-sarcoma GTPase (Ras)-like without CAAX-1 (RIT1, SOS Ras/Rac (calcified aortic stenosis) guanine nucleotide-exchange factor (GEF)-1 (SOS1) genes), Turner (X0), Hennekam (ORPHA:2136, collagen and calcium-binding epidermal growth factor (EGF) domain-1 (CCBE1) gene) [8, 9].