In our RA cohort, we observed that selective markers were differentially expressed among female and male patients, with sVCAM-1 (p = 0.06), MMP3 (p < 0.01) and PP (p < 0.05) being higher in male vs. female, and Leptin (p < 0.05) being higher in female vs. male (Supplementary Fig. 1B). Here, MMP3 is linked to rheumatoid arthritis.