The most frequent TRAEs of any grade were increased alanine aminotransferase (71.6%), increased aspartate aminotransferase (68.9%), decreased appetite (58.1%), lymphopenia (56.8%), hypoalbuminemia (55.4%), electrolyte disorder (48.6%), anemia (47.3%), thrombocytopenia (41.9%), fatigue (39.2%), pyrexia (36.5%), leukopenia (33.8%), and nausea (33.8%). The gene discussed is GPT; the disease is anemia.