IGKV2D-29 and atherosclerosis: Adenosine exerts its effects by activating A2A or A2B receptors: activation of A2A receptors inhibits the production of inflammatory cytokines TNF-α and CXCL10 to reduce inflammation, while activation of A2B receptors suppresses vascular smooth muscle cell proliferation to slow the progression of atherosclerosis [23, 24].