SFX-01 also induced STAT1 phosphorylation as well as loss of cyclin D1 expression in the human acute myelomonocytic leukemia GDM-1 cell line that expresses an activating Shp2 mutation associated with JMML and NS (Fig. 5B). The gene discussed is PTPN11; the disease is acute myelomonocytic leukemia M4.