MLST8 and neoplasm: Similar reductions in glycolytic ECAR and extracellular lactate are observed in MLST8-deficient H596 and KLN205-Ptennull Mlst8-KO cells (Fig. 4D–H), while lactate levels were decreased in tumor interstitial fluid of KLN205-Ptennull Mlst8-KO tumors (Fig. 4I).