To investigate how mTORC2 may regulate SELPLG/PSGL-1 expression in tumor cells, we found that MLST8-KO cells exhibited a significant decrease in expression of EPAS1, the gene encoding HIF2α (Fig. 5A–C) which was previously shown to be regulated by mTORC2 [16, 37]. This evidence concerns the gene MLST8 and neoplasm.