To identify genetic vulnerability of the mTORC2 pathway in LUSC, we first assessed the frequency of molecular alterations in PI3K and AKT signaling in the two predominant non-small cell lung cancer (NSCLC) subtypes, lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.