Although overall CD45+ immune cells and infiltrated CD8+ T cells were unchanged, CD8+ T cells in MLST8-KO tumors had increased expression of the activation marker CD25+ and the degranulation marker CD107a+ compared to WT controls (Fig. 3B–D, S3A), suggesting that reduced mTORC2 activity in tumor cells may create a more favorable tumor microenvironment for CD8+ T cell function. This evidence concerns the gene CD8A and neoplasm.