The inferred cell-gene interaction network analysis identified several divergent interactions previously associated with chemoresistance, where signalling via Amphiregulin (AREG), Fibronectin (FN1), CD52 and CD55 from myeloid cells, CAFs, leucocytes and cancer cells respectively, was increased in non-responders (Fig. S5B) [45–48]. Here, AREG is linked to cancer.