CDA treatment was limited to supportive care for many years until 1995, when Lavabre-Bertrand et al. unexpectedly reported that interferon-alpha (IFN-α) was effective in treating CDA-I in a 28-year-old patient with concomitant CDA-I and hepatitis C [3]. The gene discussed is IFNA1; the disease is Congenital dyserythropoietic anemia type I.