The mechanism by which ApoC-III increases triglycerides involves LPL-related and LPL-independent mechanisms but is not completely understood, given that ApoC-III ASO and siRNA molecules markedly decrease triglycerides and increase HDL-C even in patients with persistent chylomicronemia or familial chylomicronemia syndrome who have little to no functional LPL37,38,40. Here, LPL is linked to familial chylomicronemia syndrome.