Zhang X et al. detected a higher salivary Fn median relative abundance in CRC than in colorectal adenoma (CRA, a subgroup of CRP), hyperplastic polyp (HP, a subtype of serrated CRP, which is a broader subgroup of CRP), and healthy controls (CRC 1.324 [IQR 0.338–5.134] vs. CRA 0.209 [IQR 0.147–0.688] vs. HP 0.076 [IQR 0.046–0.389] vs. healthy 0.105 [IQR 0.018–0.203]; p < 0.001, in their training cohort, and CRC 2.352 [IQR 1.290–6.743] vs. CRA 0.230 [IQR 0.125–1.310] vs. HP 0.190 [IQR 0.145–0.605] vs. healthy 0.250 [IQR 0.165–0.560]; p < 0.001) in their test cohort. Here, FN1 is linked to colorectal adenoma.