Villar-Ortega et al. showed significantly higher odds for the positivity of Fn in CRC than in CRA tissue biopsies (OR 3.244; 95% CI: 2.359 − 4.462), as well as in healthy controls (OR 4.558; 95% CI: 3.312–6.272)31. Here, FN1 is linked to colorectal carcinoma.