Risk factors for developing the condition, including blunt traumatic extremity injuries, fractures (particularly distal radius fractures; potentially related to high risk for CRPS in women), sprains, different surgical procedures, nerve injuries like carpal tunnel syndrome (CTS), fibromyalgia, migraine, cigarette smoking, ACE inhibitor therapy and less frequently seen in rheumatoid arthritis, have been vaguely identified1,2,4,8–11. Here, ACE is linked to carpal tunnel syndrome.