SUMO-specific peptidase 2 (SENP2)-catalyzed deSUMOylation leads to cGAS degradation during the late stages of viral infection.380 Conversely, deSUMOylation mediated by SENP7 enhances cGAS activation by alleviating SUMO-induced inhibition of cytosolic DNA sensing.381 Furthermore, phosphorylation of h-cGAS by AKT, cyclin-dependent kinase 1 (CDK1), protein kinase, DNA-activated, catalytic subunit (PRKDC, also known as DNAPK), and aurora kinase A (AURKA) has been shown to inhibit its enzymatic activity.382–384. Here, PRKDC is linked to viral infectious disease.