The phosphorylation of innate adaptor proteins MAVS, STING, and TICAM1 at a conserved pLxIS motif is indispensable for the recruitment of IRF3 and the subsequent production of IFN-Is, demonstrating the essential function of protein phosphorylation in activating innate immune sensing and signaling in response to viral infection. The gene discussed is MAVS; the disease is viral infectious disease.