TLR7 and autoimmune disease: This process facilitates endosomal uptake of nucleic acids, shielding them from nuclease degradation and subsequently inducing TLR7- and TLR9-mediated production of IFN-Is and TNF-α in diverse immune cells, such as B cells and pDCs.344,505 The IFN-Is and cytokines triggered by TLRs trigger inflammation, creating a positive feedback loop that exacerbates autoimmune disease progression.