RIGI and viral infectious disease: The DDX helicase domains embedded in RIG-I and MDA-5 regulate antiviral immunity by controlling nuclear export of host mRNAs essential for viral RNA detection pathways.323 For instance, DDX46 suppresses IFN-I responses during viral infection by sequestering MAVS, TRAF3, and TRAF6 transcripts in the nucleus, preventing their translation.324 The presence of m6A on these mRNAs promotes their nuclear export, exemplifying the modification’s role in subcellular RNA trafficking.325