AIM2’s inflammasome-dependent function plays a crucial role in sensing microbial DNA during infections and is implicated in tumorigenesis and a range of inflammatory and autoimmune disorders, including atherosclerosis, neuroinflammation, psoriasis, dermatitis, arthritis, systemic lupus erythematosus (SLE), liver disease,129,130 and colitis. This evidence concerns the gene AIM2 and systemic lupus erythematosus.