UPR-derived endogenous RNAs serve as pathogen-associated molecular patterns (PAMPs) that trigger RIG-I-mediated type I interferon responses in the absence of the functional SKI2 subunit of super killer complex (SKIC2, also known as ski2-like RNA helicase [SKIV2L]), which is associated with susceptibility to SLE.475 Furthermore, the self-RNA–RLR axis has been explored in cancer research. The gene discussed is SKIC2; the disease is cancer.