TLR4 and neoplasm: This process restricts fat accumulation, hepatic inflammation, and fibrogenic activation in hepatic stellate cells, ultimately alleviating steatohepatitis in mice fed a high-fat diet or a methionine- and choline-deficient diet.303 In addition, miR-182, induced by TGF-β signaling in tumor-associated macrophages (TAMs), directly represses TLR4 expression by dose-dependently inhibiting TLR4 3’ UTR activity.