For example, the tumor-inhibitory functions of inflammasomes containing NLRP6, one of the most abundantly expressed PRRs in the colon, include maintaining epithelial barrier integrity through intestinal epithelium self-renewal.545 NLRP6 also regulates the secretion of IL-18 and antimicrobial peptides in enterocytes,546 as well as mucin production in goblet cells,547 which contributes to its ability to prevent the invasion of pathobionts that initiate colitis-associated colorectal cancer548 (Fig. 13). The gene discussed is IL18; the disease is colitis.