IFIH1 and viral infectious disease: Adenosine triphosphate (ATP) hydrolysis leads to the dissociation of both LGP2 and MDA-5 from dsRNA, and the dissociated MDA-5 retains its conformation with an exposed CARD.71 These unique features of LGP2 provide insight into its differential regulation of RIG-I and MDA-5, highlighting the complexity of innate immune responses to viral infections.