HDAC1 and cancer: This complex recruits the histone deacetylase 1 (HDAC1), which removes the H3K27ac modification from the promoter, thereby suppressing MARCKS transcription and subsequently reducing Ca2+ signaling and inflammatory gene expression.497 Looking ahead, the challenges lie in deciphering the intricate mechanisms underlying these integrated networks of interactions and, crucially, assessing whether therapeutic modulation of TLR-regulated and TLR-regulating ncRNAs can benefit patients with cancer or inflammatory diseases.