FASN and Sepsis: Earlier research predominantly focused on exogenous saturated fatty acids, which have been implicated in directly activating TLR6 or remodeling plasma membrane lipid raft architecture.417 Conversely, fatty acid synthase (FASN) produces endogenous de novo fatty acids that serve as vital regulators of signal transduction, modulating TLR signaling through mechanisms distinct from established pathways.418,419 Research in murine sepsis models reveals that MYD88 palmitoylation dynamics depend on both endogenous fatty acid biosynthesis and CD36-dependent exogenous fatty acid incorporation.