Specifically, they showed that a deficiency in cGAS rescues the lethality associated with TREX1 deficiency.507,508 These compelling findings indicate that the accumulation of cytoplasmic DNA in cells can activate the cGAS–STING pathway, leading to an IFN response and potentially predisposing individuals to autoimmunity, as demonstrated in these mouse models. The gene discussed is STING1; the disease is Autoimmunity.