This assembly results in the activation of IKKα/IKKβ, which subsequently promotes the transcription of NF-κB and stimulates the production and release of pro-inflammatory factors.256 In models of acute kidney injury induced by LPS and kidney ischemia/reperfusion (I/R) injury, peroxiredoxin 1 (PRDX1) has been found to promote the polarization of M1 macrophages. The gene discussed is PRDX1; the disease is acute kidney injury.