Notably, cit-vimentin/cit-fibrinogen was rarely detected in the circulation of risk-RA individuals in the aforementioned studies by James et al and Turcinov et al, which might further strengthen the hypothesis of ongoing homing of cells to lymphoid organs.8 119 In summary, there are indications of T cell alterations towards B cell interaction and proinflammatory features of both CD4+ and CD8+ T cells in the LNs of at-risk individuals. Here, CD4 is linked to rheumatoid arthritis.