None of the risk-RA individuals progressed to RA during the follow-up period.123, 126 Anang et al showed that while the frequencies of CD4+T cells and CD4+CXCR5+ T-follicular helper cells (Tfh) were higher in RA in comparison to HCs, the at-risk group ended up in-between. Here, CXCR5 is linked to rheumatoid arthritis.