We assessed the therapeutic potential of these molecules by determining their efficacy in terms of improving metabolic parameters in db/db mice which are widely considered a gold-standard model of type 2 diabetes with a phenotype of severe obesity, hyperglycaemia and dyslipidaemia due to a spontaneous mutation of leptin receptor (Leprdb) which in homozygous db/db mice leads to hyperphagia [28]. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.