Exposure to luminal fructose for 14 days in neonatal rats increased GLUT5 expression and intestinal fructose absorption, analogous to the increased fructose transport seen in hepatocytes in our study.65 Similarly, the intracellular protein TXNIP has been shown to not only regulate glucose transport but also induce intestinal fructose uptake in the diabetic state.66 Studies on the regulation of the expression of hexose transporters in MASLD and NASH have been limited. The gene discussed is TXNIP; the disease is metabolic dysfunction-associated steatotic liver disease.